Showing posts with label Mediterranean diet. Show all posts
Showing posts with label Mediterranean diet. Show all posts

Saturday, 24 May 2014

HEALTH ALERT: Study Unveils How Mediterranean Diet Protects from Hypertension

Study Unveils How Mediterranean Diet Protects from Hypertension
 - Blogs
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Move over apple—a salad a day may be the new key to a healthy heart. New research shows a diet that combines unsaturated fats with nitrite-rich vegetables, such as olive oil and lettuce, can keep hypertension at bay. The research helps explain why some previous studies have shown that a Mediterranean diet can reduce blood pressure.

The Mediterranean diet typically includes unsaturated fats found in olive oil, nuts and avocados, along with vegetables like spinach, celery and carrots that are rich in nitrites and nitrates. When these two food groups are combined, the reaction of unsaturated fatty acids with nitrogen compounds in the vegetables results in the formation of nitro fatty acids.

Researchers at King’s College London used mice to investigate the process by which these nitro fatty acids lower blood pressure, looking at whether they inhibited an enzyme known as soluble epoxide hydrolase, which regulates blood pressure.

Mice genetically engineered to be resistant to this inhibitory process were found to maintain their high blood pressure despite being fed the type of nitro fatty acids that normally form when a Mediterranean diet is consumed. However, nitro fatty acids were found to lower the blood pressure of normal mice following the same diets.
Thus, the study concludes that the protective effect of the Mediterranean diet, combining unsaturated fats and vegetables abundant in nitrite and nitrate, comes at least in part from the nitro fatty acids generated which inhibit soluble epoxide hydrolase to lower blood pressure.

The study was published in the journal PNAS.

Luckily, many consumers are aware of the benefits of consuming fruits and vegetables. According to the International Food Information Council (IFIC) 2014 Food & Health Survey, 83 percent of Americans have made an effort in the past year to consume more fruits and vegetables. And the survey showed two out of five Americans were able to identify nuts, avocados, olive oil, salmon and canola oil as foods containing high amounts of unsaturated fats.

Especially beneficial to heart health are long-chain omega-3 fatty acids—eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA)—which have been shown to lower a blood fat called triglyceride. Food Product Design spoke on the topic with Bruce Holub, Ph.D., department of human health & nutritional sciences, University of Guelph. (View the complete video on Food Product Design’s FoodTech Toolbox).

Holub cited American Heart Association recommendations of 1,000 mg per day of EPA/DHA, and 3,000 to 4,000 mg per day for those trying to lower triglycerides. However, he continued to note the average intake in America for EPA/DHA sits around 130 mg per day.

“How do we increase the intakes?" Holub asked. Simple—increase consumption of fish or functional foods that have DHA/EPA added to them.

As mentioned in Food Product Design’s Digital Issue, “Functional Foods," EPA and DHA are appearing in an array of products, including baked goods, bars, smoothies, beverages, yogurts, dressings, mixes and more.
Food product designers can formulate foods with omega-3 fatty acids using a number of methods, including encapsulation technologies and process technologies. The difference in methods is how various ingredient technologies protect lipids from oxidation and how they further prevent oxidation when incorporated in the food or beverage matrix. Choosing the appropriate method is crucial, as it will ensure finished-product quality. For a deeper look at designing foods with omega-3s, download the free Digital Issue here.


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Sunday, 18 August 2013

HEALTH ALERT: Both a Mediterranean Diet and Diets Low in Available Carbohydrates Protect Against Type 2 Diabetes, Study Suggests

Both a Mediterranean Diet and Diets Low in Available Carbohydrates Protect Against Type 2 Diabetes, Study Suggests

Published in Science Daily

Aug. 15, 2013 — New research shows that a Mediterranean-style diet and diets low in available carbohydrates can offer protection against type 2 diabetes. The study is published in Diabetologia, the journal of the European Association for the Study of Diabetes (EASD), and is by Dr Carlo La Vecchia, Mario Negri Institute of Pharmacological Research, Milan, Italy, and colleagues.

The authors studied patients from Greece who are part of the ongoing European Prospective Investigation into Cancer and nutrition (EPIC), led by Dr. Antonia Trichopoulou, from the University of Athens. From a total of 22,295 participants, actively followed up for just over 11 years, 2,330 cases of type 2 diabetes were recorded. To assess dietary habits, all participants completed a questionnaire, and the researchers constructed a 10-point Mediterranean diet score (MDS) and a similar scale to measure the available carbohydrate (or glycaemic load [GL]) of the diet.
People with an MDS of over 6 were 12% less likely to develop diabetes than those with the lowest MDS of 3 or under. Patients with the highest available carbohydrate in their diet were 21% more likely to develop diabetes than those with the lowest. A high MDS combined with low available carbohydrate reduced the chances of developing diabetes by 20% as compared with a diet low in MDS and high in GL.
The authors say: "The role of the Mediterranean diet in weight control is still controversial, and in most studies from Mediterranean countries the adherence to the Mediterranean diet was unrelated to overweight. This suggests that the protection of the Mediterranean diet against diabetes is not through weight control, but through several dietary characteristics of the Mediterranean diet. However, this issue is difficult to address in cohort studies because of the lack of information on weight changes during follow-up that are rarely recorded."
They point out that a particular feature of the Mediterranean diet is the use of extra virgin olive oil which leads to a high ratio of monounsaturated to saturated fatty acids. But again research here has been conflicting. One review of dietary fat and diabetes suggests that replacing saturated and trans fats with unsaturated fats has beneficial effects on insulin sensitivity and is likely to reduce the risk of type 2 diabetes. However, in a randomized trial of high-cardiovascular-risk individuals who were assigned to the Mediterranean diet supplemented with either free extra virgin olive oil or nuts and were compared with individuals on a low-fat diet (comparison group), there was no difference in diabetes occurrence between the two variants of the Mediterranean diet when compared with the comparison group.
Regarding GL, the authors say: "High GL diet leads to rapid rises in blood glucose and insulin levels. The chronically increased insulin demand may eventually result in pancreatic β cell failure and, as a consequence, impaired glucose tolerance and increased insulin resistance, which is a predictor of diabetes. A high dietary GL has also been unfavourably related to glycaemic control in individuals with diabetes."
They conclude: "A low GL diet that also adequately adheres to the principles of the traditional Mediterranean diet may reduce the incidence of type 2 diabetes."
Story Source:
The above story is based on materials provided byDiabetologia, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Tuesday, 28 May 2013

HEALTH ALERT: COMPOUND IN MEDITERRANEAN DIET INHIBITS CANCER CELLS

COMPOUND IN MEDITERRANEAN DIET INHIBITS CANCER CELLS

Published May 22, 2013 in Food Product Design
COLUMBUS, Ohio—A compound found in parsley, celery and other plant products, including apples, oranges and nuts that are part of the Mediterranean diet, may stop breast cancer cells from inhibiting their own death, according to a new study published online in the journal Proceedings of the National Academy of Sciences.

The findings suggest by altering a very specific step in gene regulation, the compound—apigenin—essentially re-educates cancer cells into normal cells that die as scheduled.

Much of what is known about the health benefits of nutrients is based on epidemiological studies that show strong positive relationships between eating specific foods and better health outcomes, especially reduced heart disease. But how the actual molecules within these healthful foods work in the body is still a mystery in many cases, and particularly with foods linked to lower risk for cancer.

Ohio State University researchers also showed that apigenin binds with an estimated 160 proteins in the human body, suggesting that other nutraceuticals might have similar far-reaching effects.

“We know we need to eat healthfully, but in most cases we don’t know the actual mechanistic reasons for why we need to do that," said Andrea Doseff, associate professor of internal medicine and molecular genetics at Ohio State and a co-lead author of the study. “We see here that the beneficial effect on health is attributed to this dietary nutrient affecting many proteins. In its relationship with a set of specific proteins, apigenin re-establishes the normal profile in cancer cells. We think this can have great value clinically as a potential cancer-prevention strategy."

Through additional experimentation, the team established that apigenin had relationships with proteins that have three specific functions. Among the most important was a protein called hnRNPA2. This protein influences the activity of messenger RNA, or mRNA, which contains the instructions needed to produce a specific protein. The production of mRNA results from the splicing, or modification, of RNA that occurs as part of gene activation. The nature of the splice ultimately influences which protein instructions the mRNA contains.

The researchers said abnormal splicing is the culprit in an estimated 80% of all cancers. In cancer cells, two types of splicing occur when only one would take place in a normal cell—a trick on the cancer cells’ part to keep them alive and reproducing.

In this study, the researchers observed that apigenin’s connection to the hnRNPA2 protein restored this single-splice characteristic to breast cancer cells, suggesting that when splicing is normal, cells die in a programmed way, or become more sensitive to chemotherapeutic drugs.

“So by applying this nutrient, we can activate that killing machinery. The nutrient eliminated the splicing form that inhibited cell death," Doseff said. “Thus, this suggests that when we eat healthfully, we are actually promoting more normal splice forms inside the cells in our bodies."

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