BRAIN MECHANISM STIMULATES HUNGER HORMONE IN OBESE
Posted in News, Obesity, Weight Management, Science & Research, International, Diet, Healthy, Brain Health, Nutrition, Satiety
ROUEN, France—A mechanism in the brains of obese people may affect the hunger hormone, called gherlin, causing extended appetite stimulation and overconsumption of food, according to a new study published in the journal Nature Communications.
Despite efforts, many morbidly obese people continue to consume too much food. This overconsumption of food is called hyperphagia, and has been linked to certain antibodies that affect ghrelin in obese patients, causing levels of the hunger hormone to remain at normal or even lower levels in these patients.
Researchers at the University of Rouen studied the effects of immunoglobulins, antibodies that recognize ghrelin and regulate appetite, which are found in the blood of obese patients. Using rodents, researchers administered ghrelin in combination with immunoglobulins extracted from the blood of obese patients, or with immunoglobulins derived from genetically-obese mice. Conversely, ghrelin only was given, or combined with immunoglobulins from non-obese people or mice.
When gherlin was administered with immunoglobulins extracted from obese patients or rats, food intake was stimulated more strongly. Rodents administered with gherlin only, or with gherlin combined with immunoglobulins from non-obese people or mice, were better able to regulate their appetite by restricting food intake.
Researchers found immunoglobulins bound to ghrelin to protect the hunger hormone from being broken down rapidly in the bloodstream. The ghrelin then acts on the brain for longer and stimulates appetite.
“The immunoglobulins have different properties in obese patients," said Sergueï Fetissov, researcher and main author of the study. “They are more strongly ‘attracted’ to ghrelin than in subjects of normal weight or in anorexic patients. It is this difference in ‘affinity’ that enables the immunoglobulins to transport more ghrelin to the brain and boost its stimulating action on food intake."
Research continues to identify various reasons as to why obesity rates continue to rise. In fact, earlier this year researchers from UNC School of Medicine discovered that certain parts of brain cells may play a role in eating disorders, including obesity.
Editor's note: Looking for ingredients to support your next product launch in the Weight Management category? Leading suppliers, including Kemin, Nexira, Nutratech, Pharmachem Laboratories and PL Thomas, will be at SupplySide West in Las Vegas, Nov. 12 to 16. Click here for the full exhibitor search , or register now .
Despite efforts, many morbidly obese people continue to consume too much food. This overconsumption of food is called hyperphagia, and has been linked to certain antibodies that affect ghrelin in obese patients, causing levels of the hunger hormone to remain at normal or even lower levels in these patients.
Researchers at the University of Rouen studied the effects of immunoglobulins, antibodies that recognize ghrelin and regulate appetite, which are found in the blood of obese patients. Using rodents, researchers administered ghrelin in combination with immunoglobulins extracted from the blood of obese patients, or with immunoglobulins derived from genetically-obese mice. Conversely, ghrelin only was given, or combined with immunoglobulins from non-obese people or mice.
When gherlin was administered with immunoglobulins extracted from obese patients or rats, food intake was stimulated more strongly. Rodents administered with gherlin only, or with gherlin combined with immunoglobulins from non-obese people or mice, were better able to regulate their appetite by restricting food intake.
Researchers found immunoglobulins bound to ghrelin to protect the hunger hormone from being broken down rapidly in the bloodstream. The ghrelin then acts on the brain for longer and stimulates appetite.
“The immunoglobulins have different properties in obese patients," said Sergueï Fetissov, researcher and main author of the study. “They are more strongly ‘attracted’ to ghrelin than in subjects of normal weight or in anorexic patients. It is this difference in ‘affinity’ that enables the immunoglobulins to transport more ghrelin to the brain and boost its stimulating action on food intake."
Research continues to identify various reasons as to why obesity rates continue to rise. In fact, earlier this year researchers from UNC School of Medicine discovered that certain parts of brain cells may play a role in eating disorders, including obesity.
Editor's note: Looking for ingredients to support your next product launch in the Weight Management category? Leading suppliers, including Kemin, Nexira, Nutratech, Pharmachem Laboratories and PL Thomas, will be at SupplySide West in Las Vegas, Nov. 12 to 16. Click here for the full exhibitor search , or register now .
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